Absolutely. In fact, it holds more supplies than most of the more popular diaper bags in the market, while boasting significantly more functionality. The LifeChanger has 4 mesh pouches inside that can hold: 8-12 disposable (or 4-5 cloth) diapers, wipes, change of clothes, burp clothes, creams and lotions. The outer pockets can hold wipes, snacks, bottles or sippy cups, a book or tablet, keys, money and more!